Number

Post name

Number

Job responsibilities

Job requirements

1

Research assistant

10

1. the bear and the scientific-related administrative work;

2 assistance Professor and post-doctoral, full-time researchers to complete related research work;

3）organize academic conferences and forums, to carry out domestic and foreign academic liaison;

4, is responsible for project application and other materials production, responsible for manuscripts, reports, and other research writing, editing, proofreading, etc.,

5）hosting the leadership of the account of related work.

1） Bachelor Degree or above, biochemistry and molecular biology, immunology, cell biology, bio-engineering and other related majors are preferred;

2） master the conventional cell culture, molecular biology, experimental, and other related technologies;

3） willing to actively undertake the research-related administrative work, careful, steady patience, strong sense of responsibility; a careful, responsible, willing to endure hardship; work adaptability, good communication and coordination ability, interpersonal skills and good service awareness;

2

R & D backbone of the cell process development researcher

2

1) is responsible for CAR-T, CAR-NK and other immune cells to the treatment of drug process development work;

2) responsible for the ESC, iPSC and other adult stem cell process development work;

3) to participate in the test project, experimental design, experimental operation, the results of the data analysis, the completion of the experiment report;

4) in the relevant SOP under the guidance of the work, ensure that the process development work smoothly; and

5) small test cell processes to the production of technology transfer, and assist in the production process of amplification;

6) regularly summarize and report on the experimental process and results, complete the test report;

7) write the R & D related to SOP.

1) Master Degree or above, biochemistry and molecular biology, immunology, cell biology, bio-engineering and other related majors are preferred;

2) have 2 years of biological drugs CMC process development experience is preferred;

3) solid molecular biology and cell biology based, familiar with the culture and operating principles of knowledge; good English reading and writing skills;

4) have a high sense of responsibility, meticulous work, serious and responsible, have a good team spirit, having good problem analysis and problem solving skills.

Team name

R & D direction

Professional background required

Solid tumor treatment technology team

（Director: Feng Xinhua）

Molecular targeted therapy and cellular immunotherapy and other emerging therapy compared to surgery, chemotherapy and other traditional method has many advantages, but present in solid tumors is widely used, there are still many limitations. Study of the head of the period devoted to the study of cancer occurrence and development, as well as the escape of immune surveillance of the molecular mechanisms in Cell, Nature, Nature Cell Biol, Mol Cell, PNAS, AND EMBO J, etc. of papers published more than 170 articles, and the identification of new tumor markers and therapeutic targets, and on this basis developed for different types of solid tumors of the new precision targeting therapy, including bispecific antibodies, proteolysis targeting chimeras（PTOTAC drugs, CAR-T therapy.

1, has been obtained or will obtain cell biology, molecular biology, medicine, Chemistry, Pharmacy and other related fields of doctoral degree, and have demonstrated research capabilities related to the thesis or research findings;

2. have Oncology, immunology research background and mice animal model experience candidates preferred;

3 for science exploration and tumor translational research with a strong interest in innovative thinking and scientific independence, design of experiments, and hands-on ability, can be in the PI under the guidance of carrying out independent research work;

4, have strong language skills, communication skills and critical analysis skills, good English reading and writing skills;

5 work with a positive attitude, practical work, strong sense of responsibility, has the team cooperation spirit.

Liver cancer in animal models and translational applications team

（Director: Zhao Bin）

1. the main direction for the use of mouse models to study liver cancer heterogeneity, the goal is to find liver cancer precision therapy of new targets, new markers, and the establishment of innovative pharmaceutical pre-clinical evaluation of the system;

2） the previous work in our group has been through technical innovation establishing a differentiated driving genes in the mouse liver cancer model library. The introduction of new postdoctoral we will at this unique animal model of the tool is based, on the one hand to further optimize the model, on the other hand combined with clinical resources, systemic clarify the diverse mutations lead to cancer of the liver phenotype heterogeneity of the laws and mechanisms, the discovery of new therapeutic targets and molecular markers, the evaluation of innovative drugs in the preclinical efficacy.

1 get a PhD in 3 years or will be in 2022 7 months ago biology, medicine and related fields PhD, has published a certain influence of scientific research paper results;

2）can be relatively independent of the carried out research work, in dialectical thinking, information gathering, integrated induction, academic background, and so has excellent quality;

3. have mice animal model research, Oncology research background, or bio-Informatics analysis of the ability of the candidates preferred;

4, have strong language skills and good communication skills, practical work, a sense of responsibility and team spirit;

5） there is a strong English reading, writing, listening and speaking ability, age not more than 35 years of age.

Reproductive health and transforming the application team

（Director: Van Heng Yu）

On the basis of research, mainly in the study of mammalian oocyte maturation and fertilization of regulatory mechanisms, key maternal factor in the maternal-zygotic transition in the role of research in important signal transduction molecules in follicular development and ovulation in the function.

Around the“human reproductive disease molecular diagnosis and accurate treatment”this is a core scientific issues, conduct from basic research to clinical treatment solutions and products innovative translational research, dedicated to the discovery of a batch are available for the molecular diagnosis of new genes and new molecules, and the development of a convenient test kit development to improve the human ovum and early embryo quality, the maintenance of female fertility of new technologies, new methods, the promotion of Reproductive Medicine and the accurate treatment of the development.

1 get a PhD in 3 years or will be in 2023 years ago to get biology, medical-related fields PhD, as the completion of the main people in the formal academic journals published by scientific research paper results.

2 system master the modern life Sciences theory and research philosophy, by scientific training, can be relatively independently carry out research work.

3. have mice animal model research experience, genomics research and technology or bioinformatics analysis of the ability of the candidate priority.

4, have strong language skills and good communication skills, practical work, a sense of responsibility and team spirit.

5）there is a strong English reading and writing skills, age not more than 35 years of age.

Antibodies and B cells in the treatment of the leading edge of technology development and conversion applications

（Director: Huang de force

The study group will be committed to the development with independent intellectual property rights, the level of technology exceeds the industry mainstream level, in vitro a novel high-throughput antibody screening and affinity maturation platform, lentiviral-targeted gene and drug delivery platforms, as well as on B cells genetic engineering technology platform. The study group will play more platform advantages, the development of the disease new treatment method to meet unmet medical needs. The main research and application areas:

1）autoimmune diseases new target for the discovery and proof of concept

2）tumor treatment new method development and validation

3. the preventive and therapeutic Universal Cancer Vaccine Development

4）lentivirus targeting specific cell gene editing platform building

5 research secreted protein deletion of genetic disease functional cure

1 Get biology, medical-related fields PhD in PhD can be requested in advance, and after graduation in the post, the post having a certain influence of scientific research paper results;

2. have immunological research background, the mice animal model research experience candidates preferred;

3 has a strong collaboration communication skills, practical work, has the responsibility to heart;

4, have strong execution and self-learning ability, able to mentor guidance to carry out independent research work;

5. have strong English reading communication skills.

Of primary liver cancer tumor heterogeneity of molecular mechanisms

（Director: JI Jun aromatic）

1）hepatocellular carcinoma in male incidence for Women 2-6 times, we are committed to finding non-sex hormone-dependent, positioned in an autosomal key gender differences in the expression of the gene, and parse it in hepatocellular carcinoma occur in the development of action, and possible clinical applications.

2）intrahepatic bile duct cancer onset occult, malignant degree is high, the prognosis is poor, the current clinical no use of targeted treatment options. We recently have been pioneering successfully constructed via the bile duct injection of cancer genes in the mouse liver bile duct cancer model, it is proposed to combine clinical intrahepatic cholangiocarcinoma high-frequency mutations, screening for malignant genes and their combinations, analysis of key oncogenic mechanisms, and for a given sub-type filter may be targeting scheme.

1 get a PhD in 3 years or about to get biology, medical-related fields PhD, has published a certain influence of research paper results.

2 the scientific exploration has a keen interest in innovative thinking and research independence; design of experiments and hands-on ability, in dialectical thinking, information gathering, integrated induction, academic background, have excellent qualities.

3. have mice animal model research experience, Oncology or the molecular signaling pathway research background, or bio-Informatics analysis of the ability of the candidate priority.

4, have strong language skills, communication skills; have good English listening, speaking, reading and writing, and be able to fully understand English professional literature.

5 work with a positive attitude, initiative and strong sense of responsibility and team spirit.

Protein targeting to the degradation of the technology and the development of new drugs

（Director: Jin Jianping）

Ubiquitin(Ubiquitin)is a small signaling proteins, can be connected to other protein substrates, thereby changing the protein substrates of the fate and function. Ubiquitination by the ubiquitin activating enzyme (E1), ubiquitin-coupled enzyme (E2), and ubiquitin ligase (E3) in order catalytic together. Ubiquitination one of the main results is by the 26S proteasome to degrade protein substrates. This is a eukaryotic cell within the specific degradation of the protein main routes. A large body of evidence indicates that the ubiquitin signal abnormal regulation and human diseases are closely related.

1）doctoral degree, organic synthesis, medicinal chemistry or pharmaceutical related professional, a small molecule drug synthesis experience is preferred;

2）Master of tumor cell culture, molecular biology, basic experiments and other related technologies is a plus;

3）willing to actively undertake the research-related administrative work, careful, steady patience, strong sense of responsibility; a careful, responsible, willing to endure hardship; work adaptability, good communication and coordination ability, interpersonal skills and good service awareness;

DNA cross-linking damage repair and homologous recombination repair of the molecular mechanism study

（Director: Hwang Joon）

Cells within the genome at any time faces from in vitro and in vivo of various damaging factors of the challenge, if DNA damage are not repaired in time, it will cause the cells in the cell cycle disorders, apoptosis, cancer, etc. malignant results. Therefore, how to properly complete DNA damage repair and the maintenance of genome stability, cell survival and thus prevent cancer and other major diseases occur plays a vital role. Thus, the related molecular mechanism study of DNA damage repair biology core content, for tumor diagnosis, anti-tumor drug design has important theoretical significance. The present experiment in recent years is mainly dedicated to DNA cross-linking damage repair and homologous recombination repair of the molecular mechanism study.

1, has been obtained or will obtain molecular biology, biology, or medical-related professional doctorate; and

2. have strong execution and innovative thinking, the ability to in the PI under the guidance of carrying out independent research work;

3）proactive, strong sense of responsibility, have a good sense of teamwork and coordination communication skills;

4）with a strong English expression ability and reading ability.

Protein modification and protein Life Cycle Research

（Director: Lin Shi Yin）

Lin Shi Yin laboratory was established in the end of 2017, the laboratory for Chemical Biology of cutting-edge direction to explore, and committed to the integration of Chemical Biology and biological techniques, the study of protein modification and protein life cycle. At this stage of the laboratory focus on the utility of Chemical Biology and artificial life system design, and its in basic life science research and clinical diagnostic and therapeutic applications.

1, has been obtained or will obtain chemical biology, organic chemistry, synthetic biology, biochemistry, molecular biology or cell biology, and other related professional doctorate, the special welcome with computer-aided biology research experience of the applicant;

2 for interdisciplinary research interest, with a strong Executive power and innovative thinking, it is possible in PI under the guidance of carrying out independent research work;

3 good teamwork and communication skills, strong English expression ability and reading ability;

4. special welcome with the following research experience of the researchers: computer-aided protein design, the polypeptide/protein drug development, gene therapy technology development, and delivery of technology development, protein directed evolution.