{
    "id": 93412,
    "date": "2022-12-22T14:40:03",
    "date_gmt": "2022-12-22T06:40:03",
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    "modified": "2023-04-11T15:13:26",
    "modified_gmt": "2023-04-11T07:13:26",
    "slug": "2022122201",
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        "rendered": "<section data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"89069\">\n<section>\n<section>\u8fd1\u65e5\uff0c<strong>\u897f\u5317\u5927\u5b66\u5316\u5b66\u4e0e\u6750\u6599\u79d1\u5b66\u5b66\u9662\u6a0a\u6d77\u660e\u6559\u6388\u8bfe\u9898\u7ec4\u5728\u809d\u7279\u5f02\u6027\u7eb3\u7c73\u5bf9\u6bd4\u5242\u4e0e\u78c1\u5171\u632f\u809d\u80c6\u6210\u50cf\u7814\u7a76\u65b9\u9762\u53d6\u5f97\u91cd\u8981\u8fdb\u5c55<\/strong>\uff0c\u8be5\u5de5\u4f5c\u4e0d\u4ec5\u4e3a\u8bbe\u8ba1\u517c\u5177\u9ad8\u4eb2\u548c\u6027\u4e0e\u9ad8\u7279\u5f02\u6027\u7684\u7eb3\u7c73\u5bf9\u6bd4\u5242\u63d0\u4f9b\u4e86\u65b0\u7b56\u7565\uff0c\u800c\u4e14<strong>\u4e3a\u809d\u764c\u65e9\u671f\u53d1\u73b0\u63d0\u4f9b\u4e86\u65b0\u7684\u5f71\u50cf\u8bca\u65ad\u5de5\u5177<\/strong>\u3002<\/section>\n<p>\u76f8\u5173\u6210\u679c\u4ee5<strong>\u201c<em>A Hepatocyte-targeting Nanoparticle for Enhanced Hepatobiliary Magnetic Resonance Imaging<\/em>\u201d<\/strong>\u4e3a\u9898\uff0c\u4e8e2022\u5e7412\u670819\u65e5\u5728\u7ebf\u53d1\u8868\u4e8e<strong><em>Nature Biomedical Engineering<\/em><\/strong><strong>\uff08\u81ea\u7136\u751f\u7269\u533b\u5b66\u5de5\u7a0b\uff09\u6742\u5fd7<\/strong>\uff0c\u8fd9\u662f\u5b66\u6821<strong>\u9996\u6b21<\/strong>\u5728\u8be5\u6742\u5fd7\u4e0a\u53d1\u8868\u8bba\u6587\u3002<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/image.cingta.com\/static\/image\/20221220\/c57345e5caa14f82ba4054f3d602461f.png\" alt=\"\" \/><\/p>\n<\/section>\n<\/section>\n<p>\u809d\u764c\u662f\u5168\u7403\u6700\u5e38\u89c1\u7684\u3001\u9ad8\u81f4\u547d\u6027\u809d\u810f\u6076\u6027\u80bf\u7624\u3002\u6211\u56fd\u809d\u764c\u53d1\u75c5\u4eba\u6570\u5c45\u4e16\u754c\u9996\u4f4d\uff0c\u4e145\u5e74\u603b\u4f53\u751f\u5b58\u7387\u4ec514.1%\uff0c\u9632\u6cbb\u5f62\u52bf\u5341\u5206\u4e25\u5cfb\u3002<strong>\u809d\u764c\u7684\u65e9\u671f\u8bca\u65ad\u662f\u63d0\u5347\u5176\u751f\u5b58\u7387\u548c\u6539\u5584\u9884\u540e\u7684\u5173\u952e\u3002<\/strong>\u4e0e\u5176\u4ed6\u764c\u75c7\u4e0d\u540c\uff0c\u809d\u764c\u662f\u552f\u4e00\u53ef\u901a\u8fc7\u5f71\u50cf\u8fdb\u884c\u4e34\u5e8a\u8bca\u65ad\u7684\u6076\u6027\u80bf\u7624\uff0c\u800c\u78c1\u5171\u632f\u809d\u80c6\u6210\u50cf\u88ab\u8ba4\u4e3a\u662f\u76ee\u524d\u6700\u7075\u654f\u7684\u809d\u764c\u5f71\u50cf\u8bca\u65ad\u624b\u6bb5\uff0c\u5176\u4e2d\u809d\u7ec6\u80de\u7279\u5f02\u6027\u5bf9\u6bd4\u5242\u7684\u7075\u654f\u5ea6\u548c\u7279\u5f02\u6027\u51b3\u5b9a\u4e86\u589e\u5f3a\u78c1\u5171\u632f\u6210\u50cf\u5bf9\u65e9\u671f\u809d\u764c\u8bca\u65ad\u6548\u679c\u3002\u76ee\u524d\u4e34\u5e8a\u5e94\u7528\u7684\u809d\u7ec6\u80de\u7279\u5f02\u6027\u5bf9\u6bd4\u5242\uff08\u4e3b\u8981\u4e3a\u9486\u585e\u9178\u4e8c\u94a0\uff0cGd-EOB-DTPA\uff09\u4fe1\u53f7\u589e\u5f3a\u4f4e\u3001\u7279\u5f02\u6027\u548c\u4eb2\u548c\u529b\u4e0d\u8db3\uff0c\u5bfc\u81f4\u5176\u5bf9\u5c0f\u4e8e1cm\u7684\u65e9\u671f\u809d\u764c\u5fae\u5c0f\u75c5\u7076\u96be\u4ee5\u5b9a\u6027\u68c0\u51fa\uff0c\u5bf91-2cm\u7684\u75c5\u7076\u68c0\u51fa\u7387\u4ec5\u670947%\uff08\u800c\u6b64\u65f6\u809d\u764c\u5f80\u5f80\u5df2\u53d1\u751f\u4e86\u809d\u5185\u8f6c\u79fb\uff09\uff0c\u96be\u4ee5\u6ee1\u8db3\u65e9\u671f\u809d\u764c\u7cbe\u51c6\u8bca\u65ad\u7684\u9700\u6c42\u3002<\/p>\n<p>\u8fd1\u671f\u7814\u7a76\u53d1\u73b0\uff0c\u5c3a\u5bf8\u5c0f\u4e8e5nm\u7684\u8d85\u5c0f\u94c1\u6c27\u4f53\u7531\u4e8e\u5176\u663e\u8457\u7684\u5c0f\u5c3a\u5bf8\u6548\u5e94\u53ef\u5c55\u73b0\u4e0e\u4f20\u7edf\u8d85\u987a\u78c1\u6c27\u5316\u94c1\u7eb3\u7c73\u9897\u7c92\u622a\u7136\u4e0d\u540c\u7684T1\u5f1b\u8c6b\u589e\u5f3a\u53ca\u9ad8T1\/T2\u6bd4\u7387\u7b49\u7279\u6027\uff0c\u6709\u671b\u6784\u5efa\u9ad8\u6027\u80fd\u809d\u7ec6\u80de\u7279\u5f02\u6027\u7eb3\u7c73\u5bf9\u6bd4\u5242\u3002\u7136\u800c\uff0c\u5df2\u62a5\u9053\u7684\u8d85\u5c0f\u6c27\u5316\u94c1\u5bf9\u6bd4\u5242\u7684T1\u5f1b\u8c6b\u7387\u4ec5\u4e3a4.6mM<sup>-1<\/sup>s<sup>-1<\/sup>\uff0c\u4e0e\u4e34\u5e8a\u9486\u57fa\u5bf9\u6bd4\u5242\u76f8\u6bd4\u4fe1\u53f7\u589e\u5f3a\u5e76\u65e0\u4f18\u52bf\uff1b\u4e14\u53d7\u5230\u5c0f\u5c3a\u5bf8\u53ef\u63a7\u5236\u5907\u96be\uff0c\u4ee5\u53ca\u7eb3\u7c73\u5bf9\u6bd4\u5242\u5f1b\u8c6b\u589e\u5f3a\u7406\u8bba\u53d1\u5c55\u6ede\u540e\u7684\u9650\u5236\uff0c\u96be\u4e8e\u4f18\u5316\u5176\u6027\u80fd\uff08<em>Materials Today Advances,\u00a0<\/em>2020<em>\uff1bProgress in Biomedical Engineering 2022<\/em>\uff09\u3002<\/p>\n<p>\u9488\u5bf9\u4e0a\u8ff0\u96be\u9898\uff0c\u6a0a\u6d77\u660e\u8bfe\u9898\u7ec4\u901a\u8fc7\u7cfb\u7edf\u6df1\u5165\u7814\u7a76\uff0c\u9996\u6b21\u63d0\u51fa\u4e86<strong>\u52a8\u6001\u540c\u6b65\u70ed\u5206\u89e3\u6cd5<\/strong>\uff0c\u5b9e\u73b0\u4e86\u9ad8\u5355\u5206\u6563\u3001\u5c3a\u5bf8\u53ef\u63a7\u7684\u8d85\u5c0f\u94c1\u6c27\u4f53\u7eb3\u7c73\u6750\u6599\u5b8f\u91cf\u5236\u5907\uff0c\u5e76\u4ee5\u6b64\u6784\u5efa\u4e86<strong>\u8d85\u5c0f\u9530\u94c1\u6c27\u4f53T1\u7eb3\u7c73\u5bf9\u6bd4\u5242\uff08<em>ACS Nano<\/em>, 2017\uff09<\/strong>\uff0c\u8be5\u5bf9\u6bd4\u5242\u901a\u8fc7\u5076\u8054\u9776\u5411\u80bd\uff0c\u5b9e\u73b0\u4e86\u5bf9\u6d3b\u4f53\u5c0f\u9f20\u4e73\u817a\u764c\u5168\u8eab\u8f6c\u79fb\u7624\u9ad8\u5206\u8fa8\u78c1\u5171\u632f\u663e\u50cf\uff0c\u6709\u6548\u68c0\u51fa\u4e9a\u6beb\u7c73\u7ea7\u80bf\u7624\u75c5\u7076\uff080.4mm\uff09\uff08<em>Advanced Materials<\/em>, 2019\uff09\u3002\u8bfe\u9898\u7ec4\u8fdb\u4e00\u6b65\u63ed\u793a\u8d85\u5c0f\u94c1\u6c27\u4f53\u7eb3\u7c73\u9897\u7c92\u6838\/\u58f3\u578b\u7684\u51c6\u987a\u78c1\u65b0\u7ed3\u6784\uff0c\u9610\u660e\u4e86\u8be5\u7ed3\u6784\u5bfc\u81f4\u7684\u5185\u5916\u7403T1\u5f1b\u8c6b\u534f\u540c\u589e\u5f3a\u673a\u5236\uff0c\u5b8c\u5584\u4e86\u8d85\u5c0f\u7eb3\u7c73\u5bf9\u6bd4\u5242\u5f1b\u8c6b\u589e\u5f3a\u7406\u8bba(<em>Nano Letters<\/em>, 2021\uff1b\u836f\u5b66\u8fdb\u5c55\uff0c2021)\u3002\u7279\u522b\u662f\u53d1\u73b0\u4e86<strong>\u8d85\u5c0f\u9530\u94c1\u6c27\u4f53\u7eb3\u7c73\u5bf9\u6bd4\u5242\u8868\u9762\u9530\u79bb\u5b50\u53ef\u4e0e\u809d\u7ec6\u80de\u8868\u9762SLC39A14\u86cb\u767d\u7279\u5f02\u6027\u7ed3\u5408\u5b9e\u73b0\u809d\u90e8\u589e\u5f3a\u6210\u50cf(<em>Theranostics<\/em>, 2019)<\/strong>\uff0c\u4e3a\u5176\u6784\u5efa\u9ad8\u6027\u80fd\u809d\u7ec6\u80de\u7279\u5f02\u6027\u5bf9\u6bd4\u5242\u5960\u5b9a\u4e86\u91cd\u8981\u57fa\u7840\u3002<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/image.cingta.com\/static\/image\/20221220\/8576abee10bd4e1eac28fb797d92833b.jpg\" alt=\"\" \/><\/p>\n<section><em>\u51c6\u987a\u78c1\u8d85\u5c0f\u94c1\u6c27\u4f53\u5f1b\u8c6b\u589e\u5f3a\u673a\u5236<\/em><\/section>\n<p draggable=\"true\">\u5728\u524d\u671f\u7cfb\u5217\u7814\u7a76\u7684\u57fa\u7840\u4e0a\uff0c<strong>\u8bfe\u9898\u7ec4\u7814\u7a76\u4eba<\/strong><strong>\u5458\u8bbe\u8ba1\u65b0\u578b\u3001\u53cc<\/strong><strong>\u9776\u70b9\u7684\u809d\u7ec6\u80de\u7279\u5f02\u6027\u51c6\u987a\u78c1\u8d85\u5c0f\u9530\u94c1\u6c27\u4f53\u7eb3\u7c73\u5bf9\u6bd4\u5242<\/strong>\uff08MnFe<sub>2<\/sub>O<sub>4<\/sub>-EOB-PEG\uff09\uff08<em>Nat. Biomed. Eng<\/em>. 2022\uff09\u3002\u8be5\u5bf9\u6bd4\u5242\u53ef\u901a\u8fc7\u4e0e\u809d\u7ec6\u80de\u7684SLC39A14\u548cOATP1\u4e24\u79cd\u53d7\u4f53\u9ad8\u6548\u7ed3\u5408\uff0c\u7279\u5f02\u6027\u9776\u5411\u809d\u7ec6\u80de\uff0c\u5e76\u5229\u7528\u4e24\u4e2a\u53d7\u4f53\u5747\u5728\u6b63\u5e38\u809d\u7ec6\u80de\u9ad8\u8868\u8fbe\uff0c\u80bf\u7624\u7ec6\u80de\u4f4e\u8868\u8fbe\u7684\u7279\u70b9\u5b9e\u73b0\u4e86\u65e9\u671f\u809d\u764c\u5fae\u5c0f\u75c5\u7076\u7684\u7cbe\u51c6\u5f71\u50cf\u68c0\u51fa\u3002<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/image.cingta.com\/static\/image\/20221220\/8fd2436131d14e6883cd6880b6d9ebfb.jpg\" alt=\"\" \/><\/p>\n<p><em>\u809d\u7ec6\u80de\u7279\u5f02\u6027<span lang=\"EN-US\">MnFe<sub>2<\/sub>O<sub>4<\/sub>-EOB-PEG<\/span>\u7eb3\u7c73\u5bf9\u6bd4\u5242\u8bbe\u8ba1<\/em><\/p>\n<p draggable=\"true\">\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0cMnFe<sub>2<\/sub>O<sub>4<\/sub>\u7eb3\u7c73\u9897\u7c92\u8868\u9762\u7684Mn\u79bb\u5b50\u548c\u5176\u8868\u9762\u4fee\u9970\u7684\u4e59\u6c27\u82ef\uff08EOB\uff09\u914d\u4f53\u53ef\u5b9e\u73b0\u5bf9\u809d\u7ec6\u80deSLC39A14\u548cOATP1\u7684\u53cc\u9776\u70b9\u534f\u540c\u9776\u5411\u4f5c\u7528\uff0c\u663e\u8457\u63d0\u5347\u4e86\u7279\u5f02\u6027\u548c\u4eb2\u548c\u529b\uff0c\u6d3b\u4f53\uff08\u732a\uff09\u5b9e\u9a8c\u663e\u793a\u5176\u809d\u7ec6\u80de\u7279\u5f02\u6027\u5206\u5e03\u53ef\u9ad8\u8fbe70.59%\u3002\u7334\u3001\u732a\u7b49\u5927\u52a8\u7269\u5b9e\u9a8c\u809d\u80c6\u6210\u50cf\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u4e34\u5e8aGd-EOB-DTPA\u76f8\u6bd4\uff0c\u53ef\u4f7f\u809d\u5bf9\u6bd4\u5ea6\u589e\u5f3a5.8\u500d\uff0c\u5e76\u53ef\u9ad8\u6e05\u6670\u5206\u8fa80.5\u6beb\u7c73\u7684\u809d\u7ba1\u3002\u540c\u65f6\u809d\u5b9e\u8d28\u548c\u80c6\u7ba1\u663e\u50cf\u901f\u5ea6\u4e5f\u63d0\u5347\u4e862\u500d\u4ee5\u4e0a\uff0c\u663e\u8457\u51cf\u5c11\u60a3\u8005\u68c0\u6d4b\u65f6\u95f4\uff0c\u63d0\u9ad8\u4e86\u68c0\u67e5\u6548\u7387\u3002\u6d3b\u4f53\u809d\u764c\u6210\u50cf\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u5bf9\u6bd4\u5242\u53ef\u5c06\u5fae\u5c0f\u809d\u764c\u75c5\u7076\uff08&lt;0.5\u5398\u7c73\uff09\u7684\u68c0\u51fa\u7387\u4ece48%\u63d0\u9ad8\u81f392%\uff0c\u5e76\u53ef\u6e05\u6670\u5224\u65ad\u80c6\u6897\u963b\u4f4d\u7f6e\u4e0e\u6897\u963b\u7a0b\u5ea6\uff0c\u6709\u671b\u7528\u4e8e\u65e0\u521b\u80c6\u7ba1\u6210\u50cf\u3002\u521d\u6b65\u975e\u4e34\u5e8aGLP\u8bc4\u4ef7\u548c\u5927\u52a8\u7269\u5b89\u5168\u6027\u8bc4\u4ef7\u7ed3\u679c\u5747\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u53ef\u901a\u8fc7\u809d\u3001\u80be\u5feb\u901f\u6e05\u9664\uff0c7\u5929\u6b8b\u7559\u7387\u5c0f\u4e8e1%\uff0c\u5177\u6709\u6781\u597d\u7684\u4e34\u5e8a\u8f6c\u5316\u6f5c\u529b\u3002<strong>\u8be5\u7814\u7a76\u53cc\u9776\u70b9\u8bbe\u8ba1\u7684\u65b0\u578b\u809d\u7ec6\u80de\u7279\u5f02\u6027\u51c6\u987a\u78c1\u7eb3\u7c73\u5bf9\u6bd4\u5242\u4e3a\u809d\u764c\u65e9\u671f\u53d1\u73b0\u63d0\u4f9b\u4e86\u65b0\u7684\u5f71\u50cf\u8bca\u65ad\u5de5\u5177\u3002<\/strong>MnFe<sub>2<\/sub>O<sub>4<\/sub>-EOB-PEG\u5df2\u6ce8\u518c\u5546\u6807\u201c\u73b5\u7acb\u663e\u201d\uff0c\u76ee\u524d\u5728\u897f\u5b89\u8d85\u78c1\u79d1\u6280\u8fdb\u884c\u4e34\u5e8a\u8f6c\u5316\u7814\u53d1\u3002<\/p>\n<p><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/image.cingta.com\/static\/image\/20221220\/647985ecb44b47bd8900a16dbfb9af94.jpg\" alt=\"\" \/><\/p>\n<p><em><span lang=\"EN-US\">MnFe<sub>2<\/sub>O<sub>4<\/sub>-EOB-PEG<\/span>\u7eb3\u7c73\u5bf9\u6bd4\u5242\u78c1\u5171\u632f\u809d\u80c6\u6210\u50cf<\/em><\/p>\n<section data-role=\"outer\">\n<section data-tools=\"135\u7f16\u8f91\u5668\" data-id=\"5\">\n<section>\n<section><\/section>\n<section data-role=\"outer\">\n<section>\u6a0a\u6d77\u660e\u6559\u6388\u8bfe\u9898\u7ec4\uff08<a href=\"http:\/\/www.fanlab.cn\/\" target=\"_blank\" rel=\"noopener\" 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