{"id":93412,"date":"2022-12-22T14:40:03","date_gmt":"2022-12-22T06:40:03","guid":{"rendered":"https:\/\/techtalentsuk.com\/?p=93412"},"modified":"2023-04-11T15:13:26","modified_gmt":"2023-04-11T07:13:26","slug":"2022122201","status":"publish","type":"post","link":"https:\/\/techtalentsuk.com\/en\/2022\/12\/22\/2022122201\/","title":{"rendered":"Breakthrough! Northwestern University in HCC early diagnosis areas important progress"},"content":{"rendered":"
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Recently,Northwestern University chemistry and Materials Science, College fan Sea Dr Ko teaching theme group in the liver-specific Nano-contrast agents and magnetic resonance hepatobiliary imaging studies have made important progress<\/strong>The work not only for the design of both high affinity and high specificity of nano-contrast agent provides a new strategy, andFor liver cancer early detection provide new diagnostic imaging tools<\/strong>it.<\/section>\n

Relevant outcomes to\u201cA Hepatocyte-targeting Nanoparticle for Enhanced Hepatobiliary Magnetic Resonance Imaging<\/em>\u201d<\/strong>For questions, 2022 12 May 19, published online inNature Biomedical Engineering<\/em><\/strong>\uff08Nature Biomedical Engineering journal<\/strong>This is schoolFor the first time<\/strong>In the published papers.<\/p>\n

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Liver cancer is globally the most common, highly lethal liver malignancies. My liver cancer incidence in the world, and the 5-year overall survival rate of only 14. 1% of the combat situation is very grim.Liver cancer early diagnosis is to enhance their survival rate and improve the prognosis of the key.<\/strong>With his cancer is different, liver cancer is only through the image for the clinical diagnosis of malignant tumors, and magnetic resonance hepatobiliary imaging is considered to be the most sensitive liver cancer diagnostic imaging means, wherein the hepatocyte-specific contrast agent sensitivity and specificity of the decision-enhanced magnetic resonance imaging for early cancer diagnosis. The current clinical application of hepatocyte-specific contrast agent, mainly for gadolinium plug acid disodium, Gd-EOB-DTPA signal enhancement is low, the specificity and Affinity is insufficient, which leads to less than 1cm of early liver cancer small lesions are difficult to qualitative detection of 1-2cm lesion detection rate of only 47% and at this time of liver cancer often has happened to liver metastasis, and it is difficult to meet early liver cancer accurate diagnosis of needs.<\/p>\n

A recent study found that the size of less than 5nm ultra-small ferrite due to its significantly smaller size of the effect can be demonstrated with conventional superparamagnetic iron oxide nanoparticles distinct T1 relaxation enhancement and high T1\/T2 ratio and other characteristics, is expected to build a high-performance hepatocyte-specific Nano-contrast agent. However, it has been reported that the ultra-small iron oxide contrast agent in the T1 relaxation rate of only 4. 6mM-1<\/sup>s-1<\/sup>With the clinical gadolinium-based contrast agent compared to the signal enhancement and no advantage; and by the small size of the controllable preparation difficult, and nano-contrast agent relaxation enhances the theoretical development of the hysteresis of the limit, it is difficult to optimize their performanceMaterials Today Advances,\u00a0<\/em>2020; The Progress in Biomedical Engineering 2022<\/em>it.<\/p>\n

In response to these challenges, fan Hamming research group through the system in-depth study, first proposedDynamic synchronous thermal decomposition method<\/strong>To achieve a high monodisperse, size-controllable ultra-small ferrite nanomaterials macro amount of preparation, and in order to build aUltra-small manganese ferrite T1 Nano-contrast agentsACS Nano<\/em>, 2017\uff09<\/strong>The contrast agent by coupling a targeting peptide, the realization of the living mouse breast cancer systemic metastases of high-resolution magnetic resonance imaging, the effective detection of sub-millimeter tumor lesions\uff080.4 mm\uff09\uff08Advanced Materials<\/em>, 2019 in. The research group further revealed ultra-small ferrite nanoparticles core\/shell-type quasi-paramagnetic new structure, sets out the structure of the lead inside and outside the ball T1 relaxation synergistic enhancement mechanism, improve the ultra-small nano-contrast agent relaxation enhancement theory(Nano Letters<\/em>, 2021; and a pharmaceutically acceptable progress, 2021)\u3002 In particular foundUltra-small manganese ferrite nanoparticles contrast agent to the surface of the manganese ions and the liver cell surface SLC39A14 protein that specifically binds to achieve liver-enhanced imaging(Theranostics<\/em>, 2019)<\/strong>For its build high-performance hepatocyte-specific contrast agent has laid an important Foundation.<\/p>\n

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Quasi-superparamagnetic small ferrite relaxation enhancement mechanism<\/em><\/section>\n

In the early series of studies on the basis ofThe research group studies people<\/strong>Member of the design of new, dual<\/strong>The target point of the liver cell-specific quasi-superparamagnetic small manganese ferrite Nano-contrast agent<\/strong>\uff08MnFe2<\/sub>O4<\/sub>-EOB-PEG\uff09\uff08Nat. Biomed. Eng<\/em>. 2022 airport. The contrast agent by the liver cells of SLC39A14 and OATP1 two receptors for efficient binding, specifically targeting the liver cells, and the use of the two receptors in normal liver cells with high expression of tumor cells with low expression of the characteristics to achieve early cancer of the liver tiny lesions accurate image detection.<\/p>\n

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Liver cell-specificMnFe2<\/sub>O4<\/sub>-EOB-PEG<\/span>Nano-contrast agent design<\/em><\/p>\n

Research results show that the MnFe2<\/sub>O4<\/sub>\u7eb3\u7c73\u9897\u7c92\u8868\u9762\u7684Mn\u79bb\u5b50\u548c\u5176\u8868\u9762\u4fee\u9970\u7684\u4e59\u6c27\u82ef\uff08EOB\uff09\u914d\u4f53\u53ef\u5b9e\u73b0\u5bf9\u809d\u7ec6\u80deSLC39A14\u548cOATP1\u7684\u53cc\u9776\u70b9\u534f\u540c\u9776\u5411\u4f5c\u7528\uff0c\u663e\u8457\u63d0\u5347\u4e86\u7279\u5f02\u6027\u548c\u4eb2\u548c\u529b\uff0c\u6d3b\u4f53\uff08\u732a\uff09\u5b9e\u9a8c\u663e\u793a\u5176\u809d\u7ec6\u80de\u7279\u5f02\u6027\u5206\u5e03\u53ef\u9ad8\u8fbe70.59%\u3002\u7334\u3001\u732a\u7b49\u5927\u52a8\u7269\u5b9e\u9a8c\u809d\u80c6\u6210\u50cf\u7ed3\u679c\u663e\u793a\uff0c\u4e0e\u4e34\u5e8aGd-EOB-DTPA\u76f8\u6bd4\uff0c\u53ef\u4f7f\u809d\u5bf9\u6bd4\u5ea6\u589e\u5f3a5.8\u500d\uff0c\u5e76\u53ef\u9ad8\u6e05\u6670\u5206\u8fa80.5\u6beb\u7c73\u7684\u809d\u7ba1\u3002\u540c\u65f6\u809d\u5b9e\u8d28\u548c\u80c6\u7ba1\u663e\u50cf\u901f\u5ea6\u4e5f\u63d0\u5347\u4e862\u500d\u4ee5\u4e0a\uff0c\u663e\u8457\u51cf\u5c11\u60a3\u8005\u68c0\u6d4b\u65f6\u95f4\uff0c\u63d0\u9ad8\u4e86\u68c0\u67e5\u6548\u7387\u3002\u6d3b\u4f53\u809d\u764c\u6210\u50cf\u7ed3\u679c\u663e\u793a\uff0c\u8be5\u5bf9\u6bd4\u5242\u53ef\u5c06\u5fae\u5c0f\u809d\u764c\u75c5\u7076\uff08<0.5\u5398\u7c73\uff09\u7684\u68c0\u51fa\u7387\u4ece48%\u63d0\u9ad8\u81f392%\uff0c\u5e76\u53ef\u6e05\u6670\u5224\u65ad\u80c6\u6897\u963b\u4f4d\u7f6e\u4e0e\u6897\u963b\u7a0b\u5ea6\uff0c\u6709\u671b\u7528\u4e8e\u65e0\u521b\u80c6\u7ba1\u6210\u50cf\u3002\u521d\u6b65\u975e\u4e34\u5e8aGLP\u8bc4\u4ef7\u548c\u5927\u52a8\u7269\u5b89\u5168\u6027\u8bc4\u4ef7\u7ed3\u679c\u5747\u663e\u793a\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\uff0c\u53ef\u901a\u8fc7\u809d\u3001\u80be\u5feb\u901f\u6e05\u9664\uff0c7\u5929\u6b8b\u7559\u7387\u5c0f\u4e8e1%\uff0c\u5177\u6709\u6781\u597d\u7684\u4e34\u5e8a\u8f6c\u5316\u6f5c\u529b\u3002The study of dual-target design of new liver cell-specific quasi-paramagnetic Nano-contrast agent for liver cancer early detection provide new diagnostic imaging tools.<\/strong>MnFe2<\/sub>O4<\/sub>-EOB-PEG has registered trademark\u201c\u73b5 significant legislation\u201d, is currently in XI'an ultra-magnetic technology for Clinical Translational Research.<\/p>\n

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MnFe2<\/sub>O4<\/sub>-EOB-PEG<\/span>Nano-contrast agent for magnetic resonance hepatobiliary imaging<\/em><\/p>\n

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Fan Hai Dr Ko teaching theme grouphttp:\/\/www.fanlab.cn\/<\/a>Long-term commitment to medical magnetic nano-materials and its clinical application research, dedicated to the design of efficient and safe new medical Nano-magnetic materials, the development of the matching of the magnetic medical device, create precise magnetic treatment of new technologies and new methods. Northwestern University, Zhang Dr, Sichuan University West China second hospital Guo should Kun Professor and Sun Yat-sen University Third Affiliated Hospital of focus include an associate Professor for the research paper's co-first author, Fan Hai Dr Ko granted to reprint, Singapore NUS Yong Loo Lin School of MedicineBoon-Huat Bay<\/em>Professor as the study's co-author in tumor molecular biology aspects of guidance and help, this study obtained the National Natural Science Foundation of China and the China postdoctoral Science Fund and other support.<\/section>\n<\/section>\n
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The Nature Biomedical Engineering onNature Biomedical Engineering<\/em>, Launched in 2017 1 month.The magazine included biomedical engineering significance of original research, review and comment.<\/strong>The journal relates to the field of biomedical engineering key, new breakthrough with important discoveries, such as the design of novel materials, methods, techniques or therapies to combat the disease, the design or optimization of existing medical devices and procedures before the completion of difficult tasks, and the use of Biomedical Engineering in the research to assess the health of the patient or in a variety of clinical settings and medical environment for treatment, and having obtained the leading nature, forward-looking research findings2022 year impact factor 29. 234 in.<\/strong><\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>\n<\/section>","protected":false},"excerpt":{"rendered":"

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